Aim: The aim of the study is to demonstrate the relationship between the number and distribution of microbleeding focuses with degrees of periventricular ischemia on magnetic resonance imaging (MRI) by using T2W GRE in lacunar infarct. Method: 79 patients with stroke were examined on MRI by using T2W GRE. Periventricular hyperintensity (PVH) grouped on 4 degrees by using scoring system. Microbleedings defined as a well bordered small hemosiderin deposits appear hypointense on T2W gradient echo sequence. Results: One or more microbleeding focuses had found on T2W GRE in 49.6%. Microbleedings were existed lacunar infarct in 93.7%. Pearson chi-square analysis revealed a significant relation with periventricular ischemia severity and the number of microbleedings (p<0,01). Spearman’s correlation analysis showed an advanced positive relationship between number of lacunar infarcts and number of microbleedings (r=0,429; p<0,01), number of lacunar infarcts and severity of periventricular hyperintensity (r=0,400; p<0,01) and severity of periventricular hyperintensity and number of microbleedings (r=0,773; p<0,01). Conclusion: This study revealed the relationship between lacunar infarct, periventricular white matter ischemia and hypointens focuses on T2W GRE. This MRI sequence has a role on diagnosis and treatment planning especially cerebrovascular diseases in middle and advanced ages.
@article{2021,title={Behaviors Of Cerebral Microbleedings on T2 Weighted Gradient Echo Magnetic Resonance Imaging},abstractNode={
Aim: The aim of the study is to demonstrate the relationship between the number and distribution of microbleeding focuses with degrees of periventricular ischemia on magnetic resonance imaging (MRI) by using T2W GRE in lacunar infarct. Method: 79 patients with stroke were examined on MRI by using T2W GRE. Periventricular hyperintensity (PVH) grouped on 4 degrees by using scoring system. Microbleedings defined as a well bordered small hemosiderin deposits appear hypointense on T2W gradient echo sequence. Results: One or more microbleeding focuses had found on T2W GRE in 49.6%. Microbleedings were existed lacunar infarct in 93.7%. Pearson chi-square analysis revealed a significant relation with periventricular ischemia severity and the number of microbleedings (p<0,01). Spearman’s correlation analysis showed an advanced positive relationship between number of lacunar infarcts and number of microbleedings (r=0,429; p<0,01), number of lacunar infarcts and severity of periventricular hyperintensity (r=0,400; p<0,01) and severity of periventricular hyperintensity and number of microbleedings (r=0,773; p<0,01). Conclusion: This study revealed the relationship between lacunar infarct, periventricular white matter ischemia and hypointens focuses on T2W GRE. This MRI sequence has a role on diagnosis and treatment planning especially cerebrovascular diseases in middle and advanced ages.
},author={Alptekin Tosun-İsmail Şerifoğlu -Bilge Çakır },year={2021},journal={TURKISH JOURNAL OF HEALTH AND SPORT (TJHS)}}
Alptekin Tosun-İsmail Şerifoğlu -Bilge Çakır . 2021 . Behaviors Of Cerebral Microbleedings on T2 Weighted Gradient Echo Magnetic Resonance Imaging . TURKISH JOURNAL OF HEALTH AND SPORT (TJHS).DOI:null
Alptekin Tosun-İsmail Şerifoğlu -Bilge Çakır .(2021).Behaviors Of Cerebral Microbleedings on T2 Weighted Gradient Echo Magnetic Resonance Imaging.TURKISH JOURNAL OF HEALTH AND SPORT (TJHS)
Alptekin Tosun-İsmail Şerifoğlu -Bilge Çakır ,"Behaviors Of Cerebral Microbleedings on T2 Weighted Gradient Echo Magnetic Resonance Imaging" , TURKISH JOURNAL OF HEALTH AND SPORT (TJHS) (2021)
Alptekin Tosun-İsmail Şerifoğlu -Bilge Çakır . 2021 . Behaviors Of Cerebral Microbleedings on T2 Weighted Gradient Echo Magnetic Resonance Imaging . TURKISH JOURNAL OF HEALTH AND SPORT (TJHS) . 2021. DOI:null
Alptekin Tosun-İsmail Şerifoğlu -Bilge Çakır .Behaviors Of Cerebral Microbleedings on T2 Weighted Gradient Echo Magnetic Resonance Imaging. TURKISH JOURNAL OF HEALTH AND SPORT (TJHS) (2021)
Alptekin Tosun-İsmail Şerifoğlu -Bilge Çakır .Behaviors Of Cerebral Microbleedings on T2 Weighted Gradient Echo Magnetic Resonance Imaging. TURKISH JOURNAL OF HEALTH AND SPORT (TJHS) (2021)
Format:
Alptekin Tosun-İsmail Şerifoğlu -Bilge Çakır . (2021) .Behaviors Of Cerebral Microbleedings on T2 Weighted Gradient Echo Magnetic Resonance Imaging TURKISH JOURNAL OF HEALTH AND SPORT (TJHS)
Alptekin Tosun-İsmail Şerifoğlu -Bilge Çakır . Behaviors Of Cerebral Microbleedings on T2 Weighted Gradient Echo Magnetic Resonance Imaging . TURKISH JOURNAL OF HEALTH AND SPORT (TJHS) . 2021 doi:null
Alptekin Tosun-İsmail Şerifoğlu -Bilge Çakır ."Behaviors Of Cerebral Microbleedings on T2 Weighted Gradient Echo Magnetic Resonance Imaging",TURKISH JOURNAL OF HEALTH AND SPORT (TJHS)(2021)
1. Fan YH, Mok VCT, Lam WWM, Hui AC, Wong KS. Cerebral microbleeds and white matter changes in patients hospitalized with lacunar infarcts. J Neurol 2004;251:537-41.
2. Schroeter ML, Bücheler MM, Preul C, Scheid R, Schmiedel O, Guthke T, et al. Spontaneous slow hemodynamic oscillations are impaired in cerebral microangiopathy. J Cereb Blood Flow Metab 2005;1-10.
3. Fazekas F, Kleinert R, Roob G, Kleinert G, Kapeller P, Schmidt R, et al. Histopathologic analysis of foci of signal loss on gradient-echo T2*-weighted MR images in patients with spontaneous intracerebral hemorrhage: evidence of microangiopathy-related microbleeds. AJNR 1999;20:637-42.
4. Lee SH, Bae HJ, Kwon SJ, Kim H, Kim YH, Yoon BW, et al. Cerebral microbleeds are regionally associated with intracerebral hemorrhage. Neurology 2004;13:72-6.
5. Kidwell CS, Saver JL, Villablanca JP, Duckwiler G, Fredieu A, Gough K, et al. Magnetic resonance imaging detection of microbleeds before thrombolysis: an emerging application. Stroke 2002;33:95-8.
6. Roob G, Schmidt R, Kapeller P, Lechner A, Hartung HP, Fazekas F. MRI evidence of past cerebral microbleeds in a healthy elderly population. Neurology 1999;52:991-4.
7. Koennecke HC. Cerebral microbleeds on MRI: prevalence, associations and potential clinical implications. Neurology 2006;66:165-71.
8. Hund-Georgiadis M, Ballaschke O, Scheid R, Norris DG, von Cramon DY. Characterization of cerebral microangiopathy using 3 Tesla MRI: correlation with neurological impairment and vascular risk factors. J Magn Reson Imaging 2002;15:1-7.
9. Schmidt R, Schmidt H, Fazekas F. Vascular risk factors in dementia. J Neurol 2000;247:81-7.
10. Patankar TF, Mitra D, Varma A, Snowden J, Neary D, Jackson A. Dilatation of the Virchow-Robin space is a sensitive indicator of cerebral microvascular disease: study in elderly patients with dementia. AJNR 2005;26:1512-20.
11. Kato H, Izumiyama M, Izumiyama K, Takahashi A, Itoyama Y. Silent cerebral microbleeds on T2*-weighted MRI correlation with stroke subtype, stroke recurrence, and leukoaraiosis. Stroke 2002;33:1536-40.
12. Streifler JY, Eliasziw M, Benavente OR, Alamowitch S, Fox AJ, Hachinski VC, et al. Prognostic importance of leukoaraiosis in patients with symptomatic internal carotid artery stenosis. Stroke 2002;33:1651-5.
13. Schmidt R, Fazekas F, Hayn M, Schmidt H, Kapeller P, Roob G, et al. Risk factors for microangiopathy-related cerebral damage in the Austrian stroke prevention study. J Neurol Sci 1997;152:15-21.
14. Jeong JH, Yoon SJ, Kang SJ, Choi KG, Na DL. Hypertensive pontine microhemorrhage. Stroke 2002;33:925- 9.
15. Lee SH, Kwon SJ, Kim KS, Yoon BW, Roh JK. Cerebral microbleeds in patients with hypertensive stroke. Topographical distribution in the supratentorial area. J Neurol 2004;251:1183-9.
16. Chan S, Kartha K, Yoon SS, Desmond DW, Hilal SK. Multifocal hypointense cerebral lesions on gradient-echo MR are associated with chronic hypertension. AJNR 1996;17:1821-7.
17. Nakajima K. Clinicopathologic study of pontine hemorrhage. Stroke 1983;14:485-93.
18. Fan YH, Zhang L, Lam WWM, Mok VCT, Wong KS. Cerebral microbleeds as a risk factor for subsequent intracerebral hemorrhages among patients with acute ischemic stroke. Stroke 2003;34:2459-62.
19. Chalela JA, Kang DW, Warach S. Multiple cerebral microbleeds: MRI marker of a diffuse hemorrhage-prone state. J Neuroimaging 2004;14:54-7.
study. Stroke 2002;33:735-42.
21. Rosand J, Hylek EM, O’Donnell H, Greenberg SM. Warfarin-associated hemorrhage and cerebral amyloid angiopathy: a genetic and pathologic study. Neurology 2000;55:947-51.
22. Van den Boom R, Bornebroek M, Behloul F, van den Berg-Huysmans AA, Haan J, van Buchem MA. Microbleeds in hereditary cerebral hemorrhage with amyloidosis-Dutch type. Neurology 2005;12:1288-9.
23. Walker DA, Broderick DF, Kotsenas AL, Rubino FA. Routine use of gradient-echo MRI to screen for cerebral amyloid angiopathy in elderly patients. AJR 2004;182:1547-50.
24. Racke MM, Boone LI, Hepburn DL, Parsadainian M, Bryan MT, Ness DK, et al. Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid beta. J Neurosci 2005;19:629-36.
25. Preul C, LohmannG, Hund-Georgiadis M, Guthke T, von Cramon DY. Morphometry demonstrates loss of cortical thickness in cerebral microangiopathy. J Neurol 2005;252:441-7.
26. Novak V, Abduljalil A, Kangarlu A, Slivka A, Bourekas E, Novak P, et al. Intracranial ossifications and microangiopathy at 8 Tesla MRI. Magn Reson Imaging 2001;19:1133-7.
27. Krapf H, Widder B, Skalej M. Small rosarylike infarctions in the centrum ovale suggest hemodynamic failure. AJNR 1998;19:1479-1484.
28. Schmidtke K, Hüll M. Cerebral small vessel disease: how does it progress? J Neurol Sci 2005;230:13-20.
29. Imaizumi T, Horita Y, Chiba M, Hashimoto Y, Honma T, Niwa J. Dot-like hemosiderin spots on gradient echo T2*-weighted magnetic resonance imaging are associated with past history of small vessel disease in patients with intracerebral hemorrhage. J Neuroimaging 2004;14:251-7.
30. Imaizumi T, Horita Y, Hashimoto Y, NiwaJ. Dotlike hemosiderin spots on T2*-weighted magnetic resonance imaging as a predictor of stroke recurrence: a prospective study. J Neurosurg 2004;101:915-20.
31. Ay H, Şahin G, Saatci I, Söylemezoğlu F, Sarıbaş O. Primary angiitis of the central nervous system and silent cortical hemorrhages. AJNR 2002;23:1561-3.
32. Tsushima Y, Aoki J, Endo K. Brain microhemorrhages detected on T2*-weighted gradient-echo MR images. AJNR 2003;24:88-96.
33. Oberstein SL, van den Boom R, van Buchem MA, van Houwelingen HC, Bakker E, Vollebregt E, et al. Cerebral microbleeds in CADASIL. Neurology 2001;57:1066-70.
34. Characteristic features and progression of abnormalities on MRI for CARASIL. Neurology 2015;85(5):459- 63.
35. Singhal S, Markus HS. Cerebrovascular reactivity and dynamic autoregulation in nondemented patients with CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy). J Neurol 2005;252:163-7.
37. Linn J. Imaging of cerebral microbleeds. Clin Neuroradiol 2015;25(2):167-175.
38. Takahashi W, Moriya Y, Mizuma A, Uesugi T, Ohnuki Y, Takizawa S. Cerebral microbleeds on T2*-weighted images and hemorrhagic transformation after antithrombotic therapies for ischemic stroke. J Stroke Cerebrovasc Dis 2013;22(8):e528-532.