Aim: The aim of our research is to study the relationship between the m.15452C>A variation in mitochondrial MTCYB gene and clinical findings of Turkish pediatric obese cases. The MTCYB gene encoded cytochrome b protein is one of the subunits of complex 3 which is localized in the ETS system. Complex 3 has an important function during the energy conversion which may contribute to obesity etiology. Material and Methods: Clinical and biochemical data (blood total cholesterol, triglyceride, HDL, LDL, glucose, insulin levels, HOMA-IR values and BMI Z-scores), and blood samples were collected for MTCYB gene analysis from unrelated 100 obese pediatric patients (BMI>95th percentile) and 100 nonobese (BMI between 5th and 85th percentile) healthy cases. MTCYB gene was sequenced using direct DNA sequencing analysis. The relationship between biochemical data and m.15452C>A variation was tested by t-test and Mann-Whitney U tests. Results: We found that 14 pediatric obese cases and 23 nonobese healthy cases had m.15452C>A variation. Obese cases who had m.15452C>A variation had higher blood HDL levels than other obese cases. Conclusion: The m.15452C>A variation may be related with a better plasma lipid profile in obese cases. Besides, current data provide an important step towards population genetics concerning its medical implications.
@article{2021,title={Association of the m.15452C>A Variation with Clinical Characteristics of Pediatric Obese Cases},abstractNode={
Aim: The aim of our research is to study the relationship between the m.15452C>A variation in mitochondrial MTCYB gene and clinical findings of Turkish pediatric obese cases. The MTCYB gene encoded cytochrome b protein is one of the subunits of complex 3 which is localized in the ETS system. Complex 3 has an important function during the energy conversion which may contribute to obesity etiology. Material and Methods: Clinical and biochemical data (blood total cholesterol, triglyceride, HDL, LDL, glucose, insulin levels, HOMA-IR values and BMI Z-scores), and blood samples were collected for MTCYB gene analysis from unrelated 100 obese pediatric patients (BMI>95th percentile) and 100 nonobese (BMI between 5th and 85th percentile) healthy cases. MTCYB gene was sequenced using direct DNA sequencing analysis. The relationship between biochemical data and m.15452C>A variation was tested by t-test and Mann-Whitney U tests. Results: We found that 14 pediatric obese cases and 23 nonobese healthy cases had m.15452C>A variation. Obese cases who had m.15452C>A variation had higher blood HDL levels than other obese cases. Conclusion: The m.15452C>A variation may be related with a better plasma lipid profile in obese cases. Besides, current data provide an important step towards population genetics concerning its medical implications.
},author={Durkadin Demir Eksi-Doga Turkkahraman -Anil Aktas Samur -Sema Akcurin -Ozgul M. Alper },year={2021},journal={TURKISH JOURNAL OF HEALTH AND SPORT (TJHS)}}
Durkadin Demir Eksi-Doga Turkkahraman -Anil Aktas Samur -Sema Akcurin -Ozgul M. Alper . 2021 . Association of the m.15452C>A Variation with Clinical Characteristics of Pediatric Obese Cases . TURKISH JOURNAL OF HEALTH AND SPORT (TJHS).DOI:null
Durkadin Demir Eksi-Doga Turkkahraman -Anil Aktas Samur -Sema Akcurin -Ozgul M. Alper .(2021).Association of the m.15452C>A Variation with Clinical Characteristics of Pediatric Obese Cases.TURKISH JOURNAL OF HEALTH AND SPORT (TJHS)
Durkadin Demir Eksi-Doga Turkkahraman -Anil Aktas Samur -Sema Akcurin -Ozgul M. Alper ,"Association of the m.15452C>A Variation with Clinical Characteristics of Pediatric Obese Cases" , TURKISH JOURNAL OF HEALTH AND SPORT (TJHS) (2021)
Durkadin Demir Eksi-Doga Turkkahraman -Anil Aktas Samur -Sema Akcurin -Ozgul M. Alper . 2021 . Association of the m.15452C>A Variation with Clinical Characteristics of Pediatric Obese Cases . TURKISH JOURNAL OF HEALTH AND SPORT (TJHS) . 2021. DOI:null
Durkadin Demir Eksi-Doga Turkkahraman -Anil Aktas Samur -Sema Akcurin -Ozgul M. Alper .Association of the m.15452C>A Variation with Clinical Characteristics of Pediatric Obese Cases. TURKISH JOURNAL OF HEALTH AND SPORT (TJHS) (2021)
Durkadin Demir Eksi-Doga Turkkahraman -Anil Aktas Samur -Sema Akcurin -Ozgul M. Alper .Association of the m.15452C>A Variation with Clinical Characteristics of Pediatric Obese Cases. TURKISH JOURNAL OF HEALTH AND SPORT (TJHS) (2021)
Format:
Durkadin Demir Eksi-Doga Turkkahraman -Anil Aktas Samur -Sema Akcurin -Ozgul M. Alper . (2021) .Association of the m.15452C>A Variation with Clinical Characteristics of Pediatric Obese Cases TURKISH JOURNAL OF HEALTH AND SPORT (TJHS)
Durkadin Demir Eksi-Doga Turkkahraman -Anil Aktas Samur -Sema Akcurin -Ozgul M. Alper . Association of the m.15452C>A Variation with Clinical Characteristics of Pediatric Obese Cases . TURKISH JOURNAL OF HEALTH AND SPORT (TJHS) . 2021 doi:null
Durkadin Demir Eksi-Doga Turkkahraman -Anil Aktas Samur -Sema Akcurin -Ozgul M. Alper ."Association of the m.15452C>A Variation with Clinical Characteristics of Pediatric Obese Cases",TURKISH JOURNAL OF HEALTH AND SPORT (TJHS)(2021)
